September 24th 2021

Remdesivir Ineffective in Patients Hospitalized With COVID-19 and the DisCoVeRy Trial Continues with a New Antiviral

The Discovery clinical trial was initially launched in France by Inserm in March 2020, to evaluate several possible treatments for COVID-19. Its European expansion was made possible by the EU-RESPONSE[1] project, funded by Europe. Interim analysis of the trial data had led to the recommendation to suspend the recruitment of remdesivir group patients for futility [...]
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June 28th 2021

Launch of European Covid-19 trials coordination module website

Launch of European Covid-19 trials coordination module website. The coordination module of the EU-funded projects RECOVER1 and EU-RESPONSE2 has launched its website It centralises information for academics and industry on access to the three large Pan-European adaptive platform trials currently underway: DisCoVeRy, EU-SolidAct & REMAP-CAP. A coordinated Pan-European approach is essential for tackling the [...]
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May 28th 2021

EU SolidAct – a pan-European platform for pandemic research and preparedness

EU SolidAct - a pan-European platform for pandemic research and preparedness There is an urgent need for rapid and coordinated investigation of new candidate drugs during pandemics. EU-SolidAct is an Adaptive Platform Trial developed to evaluate drug interventions in hospitalized patients with COVID-19 and to facilitate a joint European response to future pandemics. The first [...]
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April 29th 2021

Press release: Inserm and AstraZeneca join forces to test the efficacy of monoclonal antibody combination AZD7442 on Covid-19 in the European DisCoVeRy trial

April 29, 2021 – A long-acting antibody (LAAB) combination developed by AstraZeneca is to be evaluated in DisCoVeRy, the Inserm-coordinated European trial aimed at finding a treatment for COVID-19. It is planned to enroll 1240 patients across Europe in this Phase III clinical trial. With its wealth of experience in the domain of targeted therapies [...]
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October 20th 2020

Launch of the EU-RESPONSE project

The EU-RESPONSE Kick-off meeting took place on October 20th 2020 via videoconference. This meeting gathered the whole EU-RESPONSE consortium to present and discuss the planned work programme with the participation of European Commission representatives and external invitees.
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July 1st 2020

DisCoVeRy trial in practice

The DisCoVeRy clinical trial is an adaptive, randomized, open-label clinical trial, add-on of the Solidarity trial, that aims to evaluate the safety and efficacy of four antiviral therapeutic strategies as compared with standard of care. Patients are hospitalized in conventional departments or intensive care units both from academic or non-academic hospitals throughout Europe with COVID-19 [...]
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